Elucidating the mechanisms of alpha-conotoxin-induced calcium channel inhibition via G protein-coupled receptors [ 2012 - 2015 ]

Research Grant

Researchers: Dr Geza Berecki (Principal investigator) ,  Dr Evan Thomas ,  Dr Richard Clark

Brief description N-type voltage-gated calcium channels (VGCCs) are membrane proteins involved in neurotransmission and play a major role in pain. VGCCs are a well-established target for the development of analgesics. Our recent research identified that VGCCs can be inhibited by ?-conotoxins from the venom of marine snails by targeting ?-aminobutyric acid receptors in sensory neurons. We will characterize this novel form of modulation of VGCCs by ?-conotoxins and define the pathways that lead to VGCC inhibition.

Funding Amount $AUD 419,082.56

Funding Scheme Project Grants

Notes Standard Project Grant