Elucidating the mechanisms of action of and resistance to endoperoxide antimalarials [ 2014 - 2017 ]

Research Grant

Researchers: Prof Leann Tilley (Principal investigator) ,  Prof Arjen Dondorp ,  Prof Philip Rosenthal

Brief description Artemisinin-based antimalarials (ARTs) save hundreds of thousands of lives every year. Unfortunately resistance of P. falciparum to ART is now emerging in South East Asia and it is critical to know how and why. We will determine what is different about resistant parasites and will develop assays to monitor drug resistance in the field. We have found that the immature form of the malaria parasite is more resistant to ARTs, which helps explain resistance. We will build on this to develop new targetted treatments.

Funding Amount $AUD 716,755.19

Funding Scheme Project Grants

Notes Standard Project Grant