grant

Elucidating the flexibility of coreceptor engagement by HIV-1 important for macrophage tropism and escape from entry inhibitors [ 2011 - 2013 ]

Also known as: Elucidating the flexibility of coreceptor engagement by HIV-1

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1006534]

Researchers: Prof Paul Gorry (Principal investigator) ,  Prof Melissa Churchill Prof Sharon Lewin

Brief description CCR5 antagonists are a new type of anti-HIV-1 drug that stops the virus from entering cells. We have evidence to suggest that the ability of CCR5 antagonists to function properly is linked to the ability of HIV-1 to infect a type of immune cell called macrophages. In this proposal, we will investigate precisely how HIV-1 enters macrophage cells, and then determine how this may influence the outcome of patients who are receiving these drugs as part of their clinical care.

Funding Amount $AUD 635,506.67

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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