ELF5 integrates prolactin and progestin control of mammary gland development via regulation of progenitor cells. [ 2008 - 2011 ]

Research Grant

Researchers: Prof Christopher Ormandy (Principal investigator) ,  A/Pr Matthew Naylor

Brief description Elf5 may act as a master-regulator of mammary cell growth during pregnancy. We will demonstrate that Elf5 can replace the requirement for prolactin and progesterone to trigger mammary development and we will determine the stem or progenitor cells Elf5 acts on. Finally we will apply this knowledge to breast cancer cell lines to discover what role Elf5 plays in breast cancer. These experiments have the potential to establish Elf5 as a new therapeutic target for the treatment of breast cancer.

Funding Amount $AUD 720,515.94

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant