The Efficacy of N-acetylcysteine as an adjunctive treatment in unipolar depression [ 2010 - 2012 ]

Also known as: Antioxidants in depression

Research Grant

[Cite as]

Researchers: Prof Michael Berk (Principal investigator) ,  A/Pr Seetal Dodd Dr Felicity Ng Dr Olivia Dean Prof Gin Malhi
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Brief description This is evidence that the brain's antioxidant defences, particularly glutathione, are altered in depression. N-acetylcysteine (NAC), a glutathione precursor, increases antioxidant defences and has antidepressant properties in bipolar disorder. The aim of this study is to see if treatment with NAC will precent relapse and improve the symptoms of depression including functioning and quality of life. Participants will be randomly given either NAC or placebo, in addition to standard thereapy.

Funding Amount $AUD 443,832.92

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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