Effects of natural sequence variation on evasion of cytotoxic T lymphocytes by murine cytomegalovirus. [ 2009 - 2012 ]

Research Grant

Researchers: Prof Geoffrey Shellam (Principal investigator) ,  A/Pr Alec Redwood ,  A/Pr Ann Hill ,  Dr Lee Smith

Brief description Human cytomegalovirus persists for the life time of an infected person. It has many ways of achieving this, including interfering with the host immune response. This project seeks to explore this using a mouse model and murine CMV. Specifically we will focus on a set of viral genes that inhibit host recognition of virally infected cells. Sequence variation in these genes suggests that they function differently in different strains of virus: we will examine the consequences of this variation.

Funding Amount $AUD 553,167.64

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant