grant

Effects of the histone acetyltransferases MOZ and QKF on chromatin modifications [ 2011 - 2013 ]

Also known as: Effects of histone acetyltransferases on chromatin modifications

Funded by National Health and Medical Research Council
Managed by The Walter and Eliza Hall Institute of Medical Research
Managed by Walter and Eliza Hall Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1010851]

Researchers: A/Pr Anne Voss (Principal investigator) ,  A/Pr Tim Thomas

Brief description Cancer of the blood (leukaemia) can be caused by rearrangements of the genetic material (DNA) that cause fusions between ordinarily separate proteins. Monocytic leukaemia zinc finger (MOZ) fusion proteins cause aggressive leukaemia. We have shown that MOZ associates with DNA packaged with histone proteins into chromatin, changes histones and gene activity. We will examine how MOZ and the closely related QKF protein affect the chromatin to elucidate the function of MOZ and QKF.

Funding Amount $AUD 349,576.89

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Biological Sciences | Epigenetics (Incl. Genome Methylation and Epigenomics) | Genetics | basic science | cancer | chromatin | developmental biology | developmental disorders | genetic disorders | genetics | stem cell biology | transcriptional regulation |
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