The effects of ?-actinin-3 on muscle metabolism, human health and disease [ 2014 - 2016 ]

Research Grant

Researchers: Prof Kathryn North (Principal investigator) ,  Dr Kate Quinlan ,  Dr Stewart Head ,  Prof David Bishop

Brief description We have identified a common genetic variant that results in absence of the fast muscle fibre protein ?-actinin-3 in more than one billion humans worldwide. Loss of ?-actinin-3 influences elite athletic performance, muscle bulk and strength in the general population, response to diet and exercise, and susceptibility to obesity and developing type 2 diabetes. We have also demonstrated that ?-actinin-3 influence disease severity in a variety of inherited and acquired muscle disorders.

Funding Amount $AUD 643,060.45

Funding Scheme Project Grants

Notes Standard Project Grant