The effect of innate immune responses on the induction of protective immunity in murine typhoid fever [ 2003 - 2003 ]

Research Grant

Researchers: Prof Richard Strugnell (Principal investigator)

Brief description Salmonella are important pathogens of humans causing diseases ranging from gastroenteritis, typhoid fever to arthritis. Like most if not all infections, the early interaction between the host and the bacterium is characterised by very non-specific symptoms. These non-specific symptoms arise because the so-called innate immune system is activated by the infection. The purpose of this grant is to establish whether these non-specific symptoms, caused by the release of immunological homrones called cytokines, are essential to the development of an effective immune response which can protect against subsequent re-infection. This study has important implications for vaccines, of our understanding of how bacteria cause disease, and the role-capacity of the innate immune system in the development of immunity.

Funding Amount $AUD 136,500.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant