The effect of human apoE isoforms and apoE receptors on the clearance of oligomeric A 42 by hepatocytes in vitro [ 2010 - 2012 ]

Research Grant

Researchers: Prof Ralph Martins (Principal investigator) ,  Dr Ian Martins ,  Dr Matthew Sharman ,  Prof Mary Jo Ladu

Brief description Alzheimer's disease (AD) is a progressive memory disorder. Increased production of a short peptide called amyloid- (A ) aggregates to form the sticky masses in the brains of AD patients. The amount of A in the brain is a balance between production and clearance. Surprisingly, we recently demonstrated that the liver clears the majority of A . These results connect AD and cardiovascular disease (CVD), enabling current CVD therapeutics to target A clearance by the liver.

Funding Amount $AUD 424,801.80

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant