Effect of anti-IgE antibody on immune system responses and short-term outcome in acute asthma in children [ 2015 - 2018 ]

Research Grant

Researchers: Prof Peter Le Souef (Principal investigator) ,  A/Pr Guicheng Zhang ,  Dr Andrew Currie ,  Dr Anthony Bosco ,  Dr Ingrid Laing
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Brief description We plan to undertake a randomised, double-blind, placebo-controlled, clinical trial of anti-IgE antibody given at the time of an acute attack of asthma in children aged 6-12 years. The idea for this arose from our own novel data – IgE levels increase with the most common infection causing acute asthma. Given evidence the virus uses IgE to cause inflammation, giving anti-IgE during the attack should reduce the severity of the attack and produce a new, effective treatment for acute asthma.

Funding Amount $AUD 571,752.26

Funding Scheme Project Grants

Notes Standard Project Grant