The early life origin of airway smooth muscle thickening in asthma pathogenesis [ 2015 - 2019 ]

Research Grant

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Brief description Previous studies have shown that fetal growth restriction (FGR) in the womb is associated with asthma in children; however the reason remains unknown. Thickening of the airway smooth muscle (ASM) is the primary structural abnormality in asthma. A model of FGR caused by low oxygen in the womb will be used to determine if associations between FGR and asthma involve an early life increase in ASM. That ASM may be increased from birth is a novel hypothesis which challenges conventional thinking.

Funding Amount $AUD 322,198.57

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF

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