Research Grant
[Cite as http://purl.org/au-research/grants/nhmrc/1103618]Researchers: A/Pr Sandra Cooper (Principal investigator)
Brief description Membrane repair is a vital cell survival mechanism of all eukaryotic cells, using calcium-triggered vesicle fusion to ‘patch’ membrane ruptures. The muscular dystrophy protein dysferlin is a key mediator of membrane repair, although, exactly how dysferlin mends membranes has been unclear. We show that the calcium that floods through membrane tears, activates a group of enzymes called calpains, that specifically cleave dysferlin to release a specialist vesicle-fusion module for membrane repair.
Funding Amount $AUD 496,442.76
Funding Scheme Project Grants
Notes Standard Project Grant
- PURL : http://purl.org/au-research/grants/nhmrc/1103618
- nhmrc : 1103618