grant

Dynamics of hERG inactivation gating [ 2010 - 2012 ]

Also known as: Mapping the temporal sequence of events that leads to closure of the outer pore gate in an important cardiac ion channel

Funded by National Health and Medical Research Council
Managed by Victor Chang Cardiac Research Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/635520]

Researchers: Prof Jamie Vandenberg (Principal investigator)

Brief description The hERG potassium ion channel is critical for the maintenance of the normal rhythm of the heartbeat. The aim of this study is to map the temporal sequence of the movements of different parts of the hERG K+ channel that regulate the opening and closing of the extracellular gate of the channel. To achieve this, we will use the powerful protein engineering technique of phi-value analysis, a technique that has never before been applied to voltage-gated ion channels.

Funding Amount $AUD 502,437.97

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Cardiorespiratory Medicine and Haematology | Cardiology (Incl. Cardiovascular Diseases) | Medical and Health Sciences | cardiac arrhythmias | drug-induced long QT syndrome | hERG K+ channels | phi-value analysis | structure-function relationships | sudden cardiac death | voltage-clamp electrophysiology |
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