grant

Double stranded RNA - the common pathogenic agent in expanded repeat genetically inherited neurodegenerative diseases [ 2010 - 2013 ]

Also known as: RNA can be the toxic agent in a specific group of inherited neurodegenerative diseases

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/627183]

Researchers: Prof Robert Richards (Principal investigator) ,  Dr Louise O'Keefe

Brief description At least twenty human genetic diseases are due to the expansion of existing repeat sequences beyond a common threshold copy number. While many of these diseases have a common mutation mechanism and share many clinical features the molecular steps critical to their pathogenesis are not yet understood. This project will test the hypothesis that expanded repeat containing RNA, specifically in its double-stranded form, is a common pathogenic agent in many of these diseases.

Funding Amount $AUD 605,096.28

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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