[Cite as http://purl.org/au-research/grants/nhmrc/627183]
Prof Robert Richards
Dr Louise O'Keefe
Brief description At least twenty human genetic diseases are due to the expansion of existing repeat sequences beyond a common threshold copy number. While many of these diseases have a common mutation mechanism and share many clinical features the molecular steps critical to their pathogenesis are not yet understood. This project will test the hypothesis that expanded repeat containing RNA, specifically in its double-stranded form, is a common pathogenic agent in many of these diseases.
Funding Amount $AUD 605,096.28
Funding Scheme NHMRC Project Grants
Standard Project Grant