grant

How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast? [ 2018 - 2020 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1145319]

Researchers: A/Pr Michael Samuel (Principal investigator) ,  A/Pr Alexander Swarbrick

Brief description The spread of cancer from one part of the body to another (metastasis) is the main cause of cancer-related death. Metastasis is assisted by the abnormal behaviour of a population of cells called cancer-associated fibroblasts (CAFs). We have identified that activation of an enzyme called ROCK in breast cancers causes an increase in the number of CAFs. We plan to find out how ROCK activation causes this increase in CAFs and find new targets against which breast cancer therapies can be developed.

Funding Amount $AUD 645,690.97

Funding Scheme Project Grants

Notes Standard Project Grant

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