How Does Osteocalcin Reverse Glucocorticoid-Induced Dysmetabolism? [ 2015 - 2018 ]

Research Grant

Researchers: Prof Markus Seibel (Principal investigator) ,  Prof Hans Bräuner-Osborne ,  Dr Michael Swarbrick ,  Prof Hong Zhou

Brief description The benefits of glucocorticoids (GCs) are often compromised by adverse effects such as bone loss, diabetes & obesity. There is now evidence that osteocalcin regulates fuel metabolism. Osteocalcin may therefore be a potential target to prevent the adverse metabolic effects of GC therapy. We aim to determine how osteocalcin regulates energy metabolism in adipose tissue and the liver under conditions of GC excess, and whether and how osteocalcin acts through a G-protein coupled receptor.

Funding Amount $AUD 635,038.82

Funding Scheme Project Grants

Notes Standard Project Grant