How does NF-kB2 regulate thymic selection to prevent organ-specific autoimmune disease? [ 2016 - 2020 ]

Research Grant

Researchers: Prof Matthew Cook (Principal investigator) ,  Dr Stephen Daley

Brief description Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.

Funding Amount $AUD 812,992.42

Funding Scheme Project Grants

Notes Standard Project Grant