Does low dose amitriptyline reduce pain in knee osteoarthritis? A double blind, randomised, pragmatic, placebo controlled clinical trial of amitriptyline in addition to usual care [ 2015 - 2018 ]

Research Grant

Researchers: A/Pr Anita Wluka (Principal investigator) ,  Dr Andrew Teichtahl ,  Dr Donna Urquhart ,  Prof Flavia Cicuttini

Brief description Pain is the main problem for people with osteoarthritis, a common form of arthritis. This pain is not controlled well. Pain comes from structural changes in the joint. However, after time, some people develop pain due to changes in the nervous system, called pain sensitisation. This is not affected by usual treatments. Amitriptyline is used to treat pain sensitisation. This study is a randomised trial to see whether amitriptyline, relieves pain in people with knee osteoarthritis over 3 months.

Funding Amount $AUD 413,704.33

Funding Scheme Project Grants

Notes Standard Project Grant