Does enhanced vitamin D activity in bone heal the skeleton in disorders of FGF23 excess? [ 2017 - 2019 ]

Research Grant

Researchers: A/Pr Paul Anderson (Principal investigator) ,  Prof Gerald Atkins ,  Prof Howard Morris ,  Prof Rene St-Arnaud

Brief description X-linked hypophosphatemia (XLH) is a genetic disorder which results in phosphate wasting and rickets. This severe disorder has no effective treatment. We have compelling new evidence that the rickets in XLH is not primarily a disorder of low blood phosphate, but rather specific issue of low cellular levels and activity of vitamin D (1,25D) within bone. This proposal is designed to specifically demonstrate this new concept and outline a new paradigm for a new XLH treatment.

Funding Amount $AUD 875,605.69

Funding Scheme Project Grants

Notes Standard Project Grant