DNase I as Treatment for MPO-ANCA Vasculitis [ 2018 - 2021 ]

Research Grant

Researchers: Prof Stephen Holdsworth (Principal investigator)

Brief description MPO-ANCA GN is a major cause of renal failure. Current treatments are toxic and poorly effective. Excessive DNA production resulting in prominent deposits of extracellular DNA are seen in glomeruli of patients with MPO-ANCA GN. This study will look at the pathological role of DNA and in a relevant animal model, use DNase I treatment to dissolve deposited DNA and treat anti-MPO autoimmunity and GN. This evidence will allow the introduction of DNase I in clinical trials.

Funding Amount $AUD 880,496.76

Funding Scheme Project Grants

Notes Standard Project Grant