DNA vaccination using chemokine and costimulatory pathways as a treatment for chronic kidney disease [ 2009 - 2011 ]

Research Grant

Researchers: Prof David Harris (Principal investigator) ,  Dr Yiping Wang ,  Dr Yuan Min Wang ,  Prof Stephen Alexander

Brief description Chronic kidney disease (CKD) is a great burden on Australia. Treatments are mostly ineffective. Our DNA vaccination against mediators of inflammation can protect against CKD. On the basis of ongoing studies we have identified 5 candidate molecules involved in recruitment and activation of inflammatory cells. We outline studies to generate DNA vaccines to these molecules, enhance their efficacy, and test them in models that represent the 3 most important causes of human CKD.

Funding Amount $AUD 450,390.69

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant