grant

Dissecting the role of insulin-regulated phosphorylation of Rab guanine nucleotide exchange factors in GLUT4 trafficking [ 2013 - 2015 ]

Also known as: Defining how insulin regulates glucose uptake into muscle and fat, one of the major steps that is defective in Type 2 diabetes

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1047067]

Researchers: Prof David James (Principal investigator) ,  Dr Jacqueline Stoeckli Dr William Hughes Prof David Lambright

Brief description Diabetes and obesity are epidemic in the developed world. Impaired insulin action is a major cause. A key contributor is reduced glucose uptake into muscle and fat driving the pancreas to overproduce insulin. We have recently discovered three new molecules that we believe hold the secret to how insulin regulates the removal of the glucose from the blood stream after a meal. This proposal focuses on these three molecules and their regulation.

Funding Amount $AUD 628,459.45

Funding Scheme Project Grants

Notes Standard Project Grant

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