Dissecting commitment to apoptosis [ 2009 - 2011 ]

Also known as: How the Bak protein mediates apoptotic cell death, including death of cancer cells

Research Grant

[Cite as]

Researchers: Dr Ruth Kluck (Principal investigator) ,  Prof Jerry Adams Dr Jacqueline Gulbis

Brief description In cancer cells the normal process of cell death (called apoptosis) is defective, helping abnormal cells to grow and multiply unchecked. The Bak protein is a member of the Bcl-2 family of apoptosis regulators, and plays a pivotal role in mediating cell death. By defining each step in Bak-mediated apoptosis, we aim to better understand how cancer cells accumulate, and how targeting the Bcl-2 family may lead to effective anti-cancer therapeutics.

Funding Amount $AUD 582,515.50

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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