[Cite as http://purl.org/au-research/grants/nhmrc/575559]
Dr Ruth Kluck
Prof Jerry Adams
Dr Jacqueline Gulbis
Brief description In cancer cells the normal process of cell death (called apoptosis) is defective, helping abnormal cells to grow and multiply unchecked. The Bak protein is a member of the Bcl-2 family of apoptosis regulators, and plays a pivotal role in mediating cell death. By defining each step in Bak-mediated apoptosis, we aim to better understand how cancer cells accumulate, and how targeting the Bcl-2 family may lead to effective anti-cancer therapeutics.
Funding Amount $AUD 582,515.50
Funding Scheme NHMRC Project Grants
Standard Project Grant