Dissecting associations of estradiol and testosterone with cardiovascular outcomes. [ 2012 - 2014 ]

Research Grant

Researchers: Prof Bu Yeap (Principal investigator) ,  A/Pr Brendan Mcquillan ,  Prof John Beilby ,  Prof Joseph Hung ,  Prof Matthew Knuiman

Brief description Controversy persists over whether falling testosterone (T) levels in ageing men increase risk of cardiovascular disease (CVD). T is converted by the enzyme aromatase into estradiol (E2). We will assess whether men with abnormal E2 levels are at risk of CVD, more so than men with low T. We will assess whether differences in the aromatase gene which alter E2 levels also influence the risk of CVD. The results will clarify the importance of hormones to CVD and guide new approaches to its treatment.

Funding Amount $AUD 435,082.51

Funding Scheme Project Grants

Notes Standard Project Grant