Disrupted neurosteroid synthesis mediates the adverse effects of prenatal stress [ 2013 - 2015 ]

Research Grant

Researchers: Prof Jonathan Hirst (Principal investigator) ,  Dr Mary Tolcos

Brief description Maternal anxiety and related stress in pregnancy influences the fetus causing developmental changes that adversely affect the offspring leading to behavioural problems in childhood. However, mechanisms which transfer maternal changes to the fetus are unclear. We propose that disruption of the fetal-placental neurosteroid system is a major link. We will identify the deficits in this system caused by maternal stress and then examine therapies to reverse these disruptions.

Funding Amount $AUD 695,973.71

Funding Scheme Project Grants

Notes Standard Project Grant