Disorderly conduct and disturbing the peace: how loss of cell polarity and tissue architecture drives cancer progression [ 2015 - ]

Research Grant

Researchers: Prof Patrick Humbert (Principal investigator)

Brief description Disorganisation of cells within tumours is a defining feature of aggressive cancers. Using mouse models and 3D organ cultures we have now shown that disruption of a family of organising genes found in every cell confuses the arrangement, orientation and connection of cells within an organ thus causing tumours. Here we will provide a new understanding of how the disorganisation of cells in human tissue leads to cancer and develop new cancer therapeutic approaches to keep tissues well-organised.

Funding Amount $611,645.00

Funding Scheme Research Fellowships

Notes Research Fellowship