Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP260102703]Researchers: Honorary Professor Chunxia Zhao (Chief Investigator) , Yue Hui (Chief Investigator)
Brief description Biomolecular engineering of bioinspired stimuli-responsive particle systems. Lipid nanoparticles (LNPs) play a vital role in COVID-19 mRNA vaccines, yet face a challenge with only 1-2% escaping endosomes, urging the development of new nanoparticles for improved delivery. Drawing inspiration from bioinspired nanotechnology, this project aims to create virus-mimicking nanoparticles with dual stimuli-responsive properties for efficient endosomal escape. Anticipated outcomes include a novel concept inspired by virus escape mechanisms, a new class of bioinspired nanomaterials enhancing delivery efficiency, and deeper insights into endosomal escape mechanisms. The initiative promises high-value materials for drug delivery,\nbolstering Australia's standing in Advanced Biomanufacturing, Nanotechnology, and RNA therapies.
Funding Amount $766,199
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP260102703
- ARC : DP260102703