Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP210103079]Researchers: Honorary Professor Chunxia Zhao (Chief Investigator)
Brief description Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Expected outcomes and benefits include new fundamental understanding of the effect of particle mechanical properties on cell function, new insights into T cell activation and expansion, and new classes of stiffness-tunable fit-for-purpose materials for various applications in cell manufacturing.
Funding Amount $545,307
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP210103079
- ARC : DP210103079