Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP210101317]Researchers: Associate Professor Makrina Totsika (Chief Investigator) , Kathryn Fairfull-Smith (Chief Investigator) , Robert Hancock (Partner Investigator)
Brief description Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dispersal, which is critical for the discovery of anti-biofilm molecules that do not fail due to resistance development. These breakthroughs should induce a step-change in our ability to reduce the occurrence of biofilm-related infection in fields ranging from medical and veterinary to biotechnology and agriculture.
Funding Amount $458,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP210101317
- ARC : DP210101317