Discovery Projects - Grant ID: DP210101317 [ 2021-12-01 - 2025-11-30 ]

Research Grant

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Researchers: Associate Professor Makrina Totsika (Chief Investigator) ,  Kathryn Fairfull-Smith (Chief Investigator) ,  Robert Hancock (Partner Investigator)

Brief description Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dispersal, which is critical for the discovery of anti-biofilm molecules that do not fail due to resistance development. These breakthroughs should induce a step-change in our ability to reduce the occurrence of biofilm-related infection in fields ranging from medical and veterinary to biotechnology and agriculture.

Funding Amount $458,000

Funding Scheme Discovery Projects

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