Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP200102962]Researchers: Dr Yannan Yang (Chief Investigator) , Professor Michael Yu (Chief Investigator) , Professor Michael Yu (Chief Investigator) , Prof XIAOGANG QU (Partner Investigator)
Brief description Next-Generation Multifunctional Nanoparticles for mRNA Transfection. This project aims to engineer a multifunctional nanoparticle platform tailored for mRNA delivery. An innovative assembly approach will be used to design nanoparticles with adjustable composition, asymmetry and surface topography. Uniquely, three functions will be integrated in one nanoparticle, with the goal to enhance transfection efficiency in target cells. This project expects to advance knowledge of mRNA transfection mechanisms, and determine how cell-type dependent particle-mRNA interactions correlate with the nanoparticle structure and delivery performance. Outcomes include a new family of functional materials with improved mRNA delivery performance over benchmark systems to facilitate and broaden the application of mRNA technology.
Funding Amount $395,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP200102962
- ARC : DP200102962