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Discovery Projects - Grant ID: DP200101299 [ 2020-02-18 - 2024-02-17 ]

Research Grant

[Cite as https://purl.org/au-research/grants/arc/DP200101299]

Researchers: Dr Edward Gilding (Chief Investigator) ,  Dr Edward Gilding (Chief Investigator) ,  Professor David Craik (Chief Investigator) ,  Professor David Craik (Chief Investigator) ,  Thomas Durek (Chief Investigator)
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Brief description Understanding the mechanisms of peptide cyclisation. This project aims to identify, study, engineer and apply a new class of biocatalysts (called asparaginyl endopeptidase enzymes) as versatile tools for manufacturing of advanced therapeutics and bio-insecticides. The expected outcomes include fundamental new knowledge on the mechanism of action of these catalysts, an expanded toolbox for precision engineering of biomolecules and new strategies for production of high-value pharmaceuticals and crop protecting agents. The project is significant because it will contribute to high value biotechnology and agricultural industries in Australia, with the potential for economic, environmental, training and societal benefits.

Funding Amount $652,000

Funding Scheme Discovery Projects

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