Discovery Projects - Grant ID: DP180101797 [ 2018-07-01 - 2021-07-01 ]

Research Grant

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Researchers: Dr Pascal Buenzli (Chief Investigator) ,  A/Prof Alistair Evans (Chief Investigator) ,  Prof Peter Dearden (Partner Investigator) ,  Prof Jukka Jernvall (Partner Investigator)

Brief description A new universal mechanism controlling body proportions in animals. This project aims to establish that a recently-discovered mechanism, the inhibitory cascade, determines the basic proportions of appendages and body segments in a diverse range of animal groups, particularly vertebrates and arthropods. The goals of the project are to reveal the molecular mechanisms in mice and insects, and build computer simulations to show how to manipulate the control of development by the inhibitory cascade. The project should benefit bioengineering by establishing control mechanisms for the manipulation and regeneration of teeth and limbs.

Funding Amount $422,080

Funding Scheme Discovery Projects

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