Discovery Projects - Grant ID: DP170103822 [ 2017 - 2023 ]

Research Grant

[Cite as]

Researchers Prof Jamie Rossjohn; Prof James McCluskey

Brief description The project aims to understand how receptor recognition events cause intracellular signalling.Membrane-bound receptors, their cognate ligands and the ensuing intracellular activation signal determine cellular fate. The project will explore events central to cellular immunity by examining the T cell signalling machinery. This project will use labelling, crystallographic and cryo-electron microscopy studies, to determine the molecular architecture of the T cell receptor (TCR) CD3 complex, a molecular machine central to T cell signalling. This project should reveal how antigen recognition leads to T cell signal transduction which will create jobs, bring substantial health benefits and improve quality of life for Australians.

Funding Amount $556,500

Funding Scheme Discovery Projects

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