Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP170102321]Researchers: Professor Matt Sweet (Chief Investigator)
Brief description Histone deacetylase functions in immune cells. This project aims to define how an enzyme (a histone deacetylase) enables innate immune cells (macrophages) to respond to specific danger signals, such as those activating Toll-like Receptors. To identify processes that provide specificity to signal transduction pathways, this project will characterise protein targets and biological functions of a specific class IIa histone deacetylase in macrophages. This project expects to result in an understanding of histone deacetylases and protein deacetylation in immune cell responses which can be harnessed to manipulate cell functions for basic science and biotechnology uses.
Funding Amount $457,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP170102321
- ARC : DP170102321