Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP170100125]Researchers: Professor Frederic Meunier (Chief Investigator) , Professor Frederic Meunier (Chief Investigator)
Brief description Intra and intermolecular steps underpinning vesicular priming. This project aims to discover how secretory vesicles fuse with the plasma membrane, a process called priming. The fusion of secretory vesicles by exocytosis underpins neuronal communication. Despite efforts to understand vesicular fusion, how these vesicles become fusion-competent upon arrival at the plasma membrane is unknown. This project will use single molecule imaging to assess mobility changes of key priming molecules and uncover their diffusional signature during priming. It intends to build a comprehensive model of molecular interactions that make a recently docked vesicle fusion-competent. This understanding is key to unravelling how the brain works
Funding Amount $550,500
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP170100125
- ARC : DP170100125