Discovery Projects - Grant ID: DP160101623 [ 2016-01-01 - 2018-12-31 ]

Research Grant

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Researchers: Prof Edna Hardeman (Chief Investigator) ,  Dr Andrius Masedunskas (Chief Investigator) ,  Dr Tobias Meckel (Partner Investigator) ,  Dr Roberto Weigert (Partner Investigator)

Brief description Single molecule intracellular intravital imaging of actin dynamics. The project intends to develop imaging technology to visualise fundamental processes in cells within a living animal. The focus will be on the actin cytoskeleton, a dynamic macromolecular machine involved in key cellular processes including cell structure, mobility and division. It is exquisitely sensitive to environmental perturbations, requiring it to be studied in cells in living tissue. The project aims to extend the resolution of live imaging to the single molecule to understand the dynamics of actin assembly with implications for cellular processes that are hijacked in diseases. It also aims to provide a novel assay that may enable testing of the impact of drugs on cellular processes in real time.

Funding Amount $506,400

Funding Scheme Discovery Projects

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