Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP160100865]
Researchers:
Bostjan Kobe
(Chief Investigator)
,
ELIZABETH GILLAM
(Chief Investigator)
,
Professor Bostjan Kobe
(Chief Investigator)
,
Professor Bostjan Kobe
(Chief Investigator)
,
Professor Mikael Boden
(Chief Investigator)
View all 7 related researchers
Brief description Reconstructing proteins to explain and engineer biological diversity. The aim of this project is to develop computational methods to construct entirely new proteins. Computational reconstruction of enzymes that have been extinct for over 400 million years has revealed remarkable opportunities for biotechnological innovation. The intended outcomes are to develop bioinformatics methods to broaden the scope of ancestral protein reconstruction to include protein super-families, to establish what specific changes led to the evolutionary success of a protein, and to re-run evolution to generate proteins that perform in conditions suitable for industrial and agricultural applications, in particular the production of hydroxylated fatty acids for bioplastics. By examining proteins from many life forms, the project plans to develop a novel bioinformatics strategy to understand their evolution and engineer new proteins for use in production of chemical commodities.
Funding Amount $330,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP160100865
- ARC : DP160100865