[Cite as http://purl.org/au-research/grants/arc/DP150104321]
Researchers Dr Yazi Ke; Dr Janet van Eersel; Dr Thomas Fath; Prof Peter Gunning
Brief description Unrestricted brain function is essential to ones wellbeing and the ability to perform normal. Critically contributing to the function of neurons is its cytoskeleton, by maintaining morphology and function. However, molecular mechanisms underlying cytoskeletal dynamics are poorly understood. We found LIM domain kinase 1, a key regulator of the actin cytoskeleton, decreased with age, and its loss is associated with deficits in memory and neuronal morphology. We will study LIM domain kinase 1 in neuronal function, using cell and mouse models. This project will reveal fundamental processes regulating and maintaining brain function, and thereby contribute to the Strategic Research Priority ‘Promoting population health and wellbeing’.
Funding Amount 445500
Funding Scheme Discovery Projects