[Cite as http://purl.org/au-research/grants/arc/DP150102496]
Dr Jee Hyun Kim
Prof Antonio Paolini
Brief description Neural network underlying memory erasure. Memory expression can easily be reduced through the process of extinction, which involves repeated presentations of cues involved in that memory but without any outcome. In adult animals (including humans), it is widely accepted that extinction leads to a temporary inhibition of the original memory that remains largely unaltered. Remarkably, extinction causes erasure in juvenile rodents so that the original memory is permanently reduced. This is because the normal maturational changes in the brain result in fundamental developmental differences in the neural network underlying extinction. This project aims to map out this network across life, and also to reproduce the juvenile network in adult rats to erase memories via extinction in adulthood.
Funding Amount $355,100
Funding Scheme Discovery Projects
View this grant in the ARC Data Portal