[Cite as http://purl.org/au-research/grants/arc/DP140100259]
Researchers A/Prof Grigori Rychkov; Prof Gregory Barritt;
Brief description Store-operated calcium channels play a central role in the functions of all animal cells. They participate in generating the cellular responses to hormones, antigens, growth factors and other physiological stimuli. The aims of this project are to elucidate cellular mechanisms that regulate interaction between the molecular components of store-operated calcium channel, Orai and STIM. Using techniques of electrophysiology and molecular biology we expect to answer a fundamental question how STIM and Orai proteins interact to form functional store-operated calcium channels, and how the expression of STIM and Orai is regulated.
Funding Amount 390000
Funding Scheme Discovery Projects