Discovery and mechanisms of host cell factors in HIV uncoating [ 2016 - 2018 ]

Research Grant

Researchers: A/Pr Till Boecking (Principal investigator) ,  A/Pr Stuart Turville ,  Dr Yann Gambin

Brief description HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.

Funding Amount $AUD 653,108.45

Funding Scheme Project Grants

Notes Standard Project Grant