grant

Discovery of long CD8+ T cell epitopes uncovers a hidden reservoir of immunodominant, anti-tumour responses [ 2009 - 2011 ]

Also known as: Exploring hidden CD8+ T cell response to tumour antigen

Funded by National Health and Medical Research Council
Managed by Ludwig Institute for Cancer Research
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/542508]

Researchers: Prof Weisan Chen (Principal investigator) ,  Prof Jonathan Cebon

Brief description Stimulating killer T cells to eliminate tumours has been one of the ultimate yet elusive goals of cancer vaccine development. Vaccines aimed at stimulating killer T cells are similar to those generated under natural conditions. However, special strategies are needed to vaccinate beneficial killer T cells that are not normally part of the natural immunity. In this project, we will explore such a scenario and dissect the related mechanisms contributing to such differential immune outcomes.

Funding Amount $AUD 480,127.04

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Clinical Chemistry (Incl. Diagnostics) | Clinical Sciences | Immunity, cellular | T cell immunity | Vaccine development | X-ray crystallography | antigen presentation | cancer therapy | cancer vaccine | cell mediated immunity | structure | vaccine development |
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