Discovery and Characterisation of Novel Tick Evasins as Inhibitors of Chemokine-mediated Inflammation [ 2018 - 2020 ]

Research Grant

Researchers: A/Pr Martin Stone (Principal investigator) ,  Dr Meritxell Canals ,  Prof Matthew Wilce ,  Prof Richard Payne

Brief description An important aspect of inflammatory diseases is the migration of white blood cells into the affected tissues. This is controlled by a group of proteins called chemokines. Ticks, which live on mammalian hosts, produce proteins called evasins, which interact with host chemokines and thereby prevent inflammatory responses. This project will discover new tick evasins, study their chemokine interactions and investigate their ability to block inflammation in allergic asthma.

Funding Amount $AUD 664,014.85

Funding Scheme Project Grants

Notes Standard Project Grant