Directed molecular evolution of G protein-coupled receptors for stable and functional expression in Escherichia coli [ 2008 - 2013 ]

Research Grant

Researchers: Dr Daniel Scott (Principal investigator)

Brief description Approximately half of all prescription drugs on the market act on G protein coupled receptors (GPCRs). The mechanisms underlying GPCR function are mainly unknown due to a lack of structural information. No solved structures exist for any of the estimated 800 human GPCRs, making it difficult to design new drugs. By applying advanced protein engineering techniques I aim to produce human GPCRs in bacteria to ultimately acquire structural information, which will enable novel drug development.

Funding Amount $AUD 383,479.96

Funding Scheme Early Career Fellowships

Notes CJ Martin Biomedical ECF