Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. [ 2006-01-01 - 2009-06-30 ]

Research Grant

Researchers: A/Prof Lawrence Gahan (Chief Investigator) ,  Prof David Ollis (Chief Investigator) ,  Professor Gary Schenk (Chief Investigator) ,  Professor Gary Schenk (Chief Investigator) ,  The Australian National University (Managed by)

Brief description Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP residues. However, many pesticides are not removed rapidly and OP-degrading enzymes require modification(s) if they are to be useful environmental reagents - this can be achieved with directed evolution.

Funding Amount $256,000

Funding Scheme Discovery Projects

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