Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle [ 2008 - 2010 ]

Research Grant

Researchers: A/Pr Carsten Schmitz-Peiffer (Principal investigator) ,  A/Pr Todd Mitchell

Brief description We have identified a novel fat molecule in muscle which may play an important role in causing insulin resistance during obesity, a major factor in the development of Type 2 diabetes. We will now examine whether depletion of this molecule, dilinoleoyl-phosphatidic acid, can improve insulin action in muscles and in obese mice, and investigate the mechanisms by which it may act. This work may indicate new strategies for the treatment of diabetes.

Funding Amount $AUD 504,097.08

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant