Differentiation of pro-fibrotic from anti-inflammatory effects of TGF-? in kidney fibrosis by targeting ?-catenin [ 2013 - 2016 ]

Research Grant

Researchers: Dr Guoping Zheng (Principal investigator) ,  Prof David Harris (Principal investigator)

Brief description More than 2500 Australians commence kidney replacement therapy each year and many more die of kidney failure as a result of kidney fibrosis. TGF-?, a growth factor causing kidney fibrosis, is also anti-inflammatory. Our project aims to prove that targeting a downstream messenger (?-catenin) of TGF-? will prevent kidney fibrosis while leaving TGF-?’s anti-inflammatory actions untouched. A successful outcome will lead to a novel cure for preventing kidney fibrosis and fibrosis of other organs.

Funding Amount $AUD 593,019.35

Funding Scheme Project Grants

Notes Standard Project Grant