Diabolic regulation of macrophage cell death pathways by Legionella [ 2012 - 2015 ]

Research Grant

Researchers: Dr Thomas Naderer (Principal investigator) ,  Dr James Vince

Brief description The bacterial pathogen Legionella causes fatal pneumonia in immuno-compromised humans. Infections depend on a sophisticated secretion machinery that translocates hundreds of proteins into host cells. These proteins subvert several essential defense pathways, including cell death signals. This project will highlight how Legionella interfere with cell death pathways and control the survival of its host cells. These findings will facilitate the development of promising new anti-bacterial agents.

Funding Amount $AUD 616,912.50

Funding Scheme Project Grants

Notes New Investigator Grant