Diabetes exacerbates non-alcoholic steato-hepatitis (NASH) [ 2010 - 2013 ]

Research Grant

Researchers: Prof Stephen Twigg (Principal investigator) ,  A/Pr Susan Mclennan ,  Prof Mark Gorrell

Brief description Non-alcoholic steato-hepatitis (NASH) is a common disease of liver inflammation and scarring, which may progress to cirrhosis or liver cancer. While type 2 diabetes causes a higher rate of NASH and more rapid NASH progression the reasons for this are not clear. We have developed a novel animal model of NASH with diabetes added to dietary induced obesity. We show that a growth factor is elevated in the affected livers. We plan to block the growth factor to see if we can prevent NASH worsening.

Funding Amount $AUD 565,695.32

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant